2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-10284S5
    Linagliptin-d6 98%
    Linagliptin-d6 (BI 1356-d6) is deuterium labeled Linagliptin. Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.
    Linagliptin-d6
  • HY-10285AR
    Saxagliptin hydrate (Standard) 945667-22-1 98%
    Saxagliptin (hydrate) (Standard) is the analytical standard of Saxagliptin (hydrate). This product is intended for research and analytical applications. Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrate has the peotential for type 2 diabetes mellitus research.
    Saxagliptin hydrate (Standard)
  • HY-10285S1
    (rel)-Saxagliptin-13C,d2 TFA 2012595-09-2 98%
    (rel)-Saxagliptin-13C,d2 ((rel)-BMS-477118-13C,d2) TFA is 13C-labeled Saxagliptin (HY-10285).
    (rel)-Saxagliptin-13C,d2 TFA
  • HY-10285S2
    Saxagliptin-13C2 98%
    Saxagliptin-13C2 (BMS-477118-13C2) is 13C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research.
    Saxagliptin-13C2
  • HY-103007R
    TC-G-1008 (Standard) 1621175-65-2 98%
    TC-G-1008 (Standard) is the analytical standard of TC-G-1008 (HY-103007). This product is intended for research and analytical applications. TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively.
    TC-G-1008 (Standard)
  • HY-103083R
    GPR40 agonist 4 (Standard) 2102196-57-4
    GPR40 agonist 4 (Standard) is the analytical standard of GPR40 agonist 4 (HY-103083). This product is intended for research and analytical applications. GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
    GPR40 agonist 4 (Standard)
  • HY-103108R
    CJ033466 (Standard) 519148-48-2
    CJ033466 (Standard) is the analytical standard of CJ033466 (HY-103108). This product is intended for research and analytical applications. CJ033466 is a novel and selective 5-HT4 receptor partial agonist with an EC50 of 9 nM and has gastroprokinetic effect.
    CJ033466 (Standard)
  • HY-103151R
    CP94253 hydrochloride (Standard) 845861-39-4 98%
    CP94253 hydrochloride (Standard) is the analytical standard of CP94253 hydrochloride (HY-103151). This product is intended for research and analytical applications. CP94253 hydrochloride is an orally active, brain-penetrant and selective 5-HT1B receptor agonist with an Ki of 2 nM. CP94253 hydrochloride induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 hydrochloride can be used for the research of depression and heightened aggressive behavior.
    CP94253 hydrochloride (Standard)
  • HY-103173R
    5'-N-Ethylcarboxamidoadenosine (Standard) 35920-39-9 98%
    5'-N-Ethylcarboxamidoadenosine (Standard) is the analytical standard of 5'-N-Ethylcarboxamidoadenosine. This product is intended for research and analytical applications. 5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist.
    5'-N-Ethylcarboxamidoadenosine (Standard)
  • HY-103195R
    NKY80 (Standard) 299442-43-6
    NKY80 (Standard) is the analytical standard of NKY80 (HY-103195). This product is intended for research and analytical applications. NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC50s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues.
    NKY80 (Standard)
  • HY-103200R
    SR59230A hydrochloride (Standard) 1135278-41-9
    SR59230A hydrochloride (Standard) is the analytical standard of SR59230A hydrochloride (HY-103200). This product is intended for research and analytical applications. SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
    SR59230A hydrochloride (Standard)
  • HY-103238R
    RSVA405 (Standard) 140405-36-3
    RSVA405 (Standard) is the analytical standard of RSVA405 (HY-103238). This product is intended for research and analytical applications. RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity.
    RSVA405 (Standard)
  • HY-103327R
    MJ15 (Standard) 944154-76-1
    MJ15 (Standard) is the analytical standard of MJ15 (HY-103327). This product is intended for research and analytical applications. MJ15 is a potent and selective CB1 receptor antagonist with a Ki of 27.2 pM and an IC50 of 118.9 pM for rat CB1 receptors. MJ15 exhibits potency in obesity and hyperlipidemia models. MJ15 inhibits food intake and increases in body weight in diet-induced obese rats and mice.
    MJ15 (Standard)
  • HY-103334R
    MAFP (Standard) 188404-10-6 98%
    MAFP (Standard) is the analytical standard of MAFP (HY-103334). This product is intended for research and analytical applications. MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
    MAFP (Standard)
  • HY-103352R
    L-006235 (Standard) 294623-49-7 98%
    L-006235 (Standard) is the analytical standard of L-006235. This product is intended for research and analytical applications. L-006235 (L-235) is a potent, selective, reversible and orally active inhibitor of cathepsin K, with an IC50 of 5 nM in bone resorption assay. L-006235 shows selectivity for cathepsin K (Ki=0.2 nM) over cathepsin B, cathepsin L, and cathepsin S (Ki=1, 6, and 47 μM, respectively). L-006235 can reduce collagen degradation and prevent bone loss.
    L-006235 (Standard)
  • HY-103355R
    YM022 (Standard) 145084-28-2
    YM022 (Standard) is the analytical standard of YM022 (HY-103355). This product is intended for research and analytical applications. YM022 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo.
    YM022 (Standard)
  • HY-103391R
    Qc1 (Standard) 403718-45-6
    Qc1 (Standard) is the analytical standard of Qc1 (HY-103391). This product is intended for research and analytical applications. Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease.
    Qc1 (Standard)
  • HY-103478R
    KHK-IN-2 (Standard) 2135304-43-5
    KHK-IN-2 (Standard) is the analytical standard of KHK-IN-2 (HY-103478). This product is intended for research and analytical applications. KHK-IN-2 is a potent and selective ketohexokinase (KHK) inhibitor with an IC50 of 0.45 μM.
    KHK-IN-2 (Standard)
  • HY-103479R
    GOAT-IN-1 (Standard) 1452473-54-9
    GOAT-IN-1 (Standard) is the analytical standard of GOAT-IN-1 (HY-103479). This product is intended for research and analytical applications. GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.
    GOAT-IN-1 (Standard)
  • HY-103546R
    BETP (Standard) 1371569-69-5
    BETP (Standard) is the analytical standard of BETP (HY-103546). This product is intended for research and analytical applications. BETP is an agonist of glucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755 μM for human and rat GLP-1 receptor, respectively.
    BETP (Standard)
Cat. No. Product Name / Synonyms Application Reactivity